Four infinite families of ternary cyclic codes with a square-root-like lower bound

Cyclic codes are an interesting type of linear codes and have wide applications in communication and storage systems due to their efficient encoding and decoding algorithms. Inspired by the recent work on binary cyclic codes published in IEEE Trans. Inf. Theory, vol. 68, no. 12, pp. 7842-7849, 2022, and the arXiv paper arXiv:2301.06446, the objectives of this paper are the construction and analyses of four infinite families of ternary cyclic codes with length $n=3^m-1$ for odd $m$ and dimension $k \in \{n/2, (n + 2)/2\}$ whose minimum distances have a square-root-like lower bound. Their duals have parameters $[n, k^\perp, d^\perp]$, where $k^\perp \in \{n/2, (n- 2)/2\}$ and $d^\perp$ also has a square-root-like lower bound. These families of codes and their duals contain distance-optimal cyclic codes

MiRNA-200b level in peripheral blood predicts renal interstitial injury in patients with diabetic nephropathy

Background: To uncover the diagnostic potential of peripheral blood microRNA-200b (miRNA-200b) in renal interstitial injury in diabetic nephropathy (DN) patients. Methods: A total of 50 diabetes subjects, 50 mild DN subjects, 50 moderate-severe DN subjects and 50 healthy subjects were included. Peripheral blood level of miRNA-200b in every subject was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Serum levels of renal function indicators were determined by enzyme-linked immunosorbent assay (ELISA). Meanwhile, relative levels of fibrosis damage indicators were examined by chemiluminescent immunoassay. Diagnostic potentials of miRNA200b in diabetes, mild DN and moderate-severe DN were assessed by depicting receiver operating characteristic (ROC) curves. Results: Peripheral blood level of miRNA-200b was higher in DN subjects than diabetes subjects without vascular complications, especially moderate-severe DN patients. Peripheral blood level of miRNA-200b in DN subjects was negatively correlated to relative levels of serum creatinine, urinary nitrogen, cystatin, TGF-b, CIV and PCIII. ROC curves demonstrated diagnostic potentials of miRNA-200b in mild and moderate-severe DN. Conclusions: Peripheral blood level of miRNA-200b is closely linked to the degree of renal interstitial injury in DN patients. MiRNA-200b may be a vital indicator in predicting the development of DN

Molecular epidemiological characteristics of Mycobacterium leprae in highly endemic areas of China during the COVID-19 epidemic

ObjectivesThe present study analyzed the impact of the COVID-19 pandemic on the prevalence and incidence of new leprosy cases, as well as the diversity, distribution, and temporal transmission of Mycobacterium leprae strains at the county level in leprae-endemic provinces in Southwest China.MethodsA total of 219 new leprosy cases during two periods, 2018–2019 and 2020–2021, were compared. We genetically characterized 83 clinical isolates of M. leprae in Guizhou using variable number tandem repeats (VNTRs) and single nucleotide polymorphisms (SNPs). The obtained genetic profiles and cluster consequences of M. leprae were compared between the two periods.ResultsThere was an 18.97% decrease in the number of counties and districts reporting cases. Considering the initial months (January–March) of virus emergence, the number of new cases in 2021 increased by 167% compared to 2020. The number of patients with a delay of >12 months before COVID-19 (63.56%) was significantly higher than that during COVID-19 (48.51%). Eighty-one clinical isolates (97.60%) were positive for all 17 VNTR types, whereas two (2.40%) clinical isolates were positive for 16 VNTR types. The (GTA)9, (TA)18, (TTC)21 and (TA)10 loci showed higher polymorphism than the other loci. The VNTR profile of these clinical isolates generated five clusters, among which the counties where the patients were located were adjacent or relatively close to each other. SNP typing revealed that all clinical isolates possessed the single SNP3K.ConclusionCOVID-19 may have a negative/imbalanced impact on the prevention and control measures of leprosy, which could be a considerable fact for official health departments. Isolates formed clusters among counties in Guizhou, indicating that the transmission chain remained during the epidemic and was less influenced by COVID-19 preventative policies

Experimental validation of motor primitive-based control for leg exoskeletons during continuous multi-locomotion tasks

An emerging approach to design locomotion assistive devices deals with reproducing desirable biological principles of human locomotion. In this paper, we present a bio-inspired controller for locomotion assistive devices based on the concept of motor primitives. The weighted combination of artificial primitives results in a set of virtual muscle stimulations. These stimulations then activate a virtual musculoskeletal model producing reference assistive torque profiles for different locomotion tasks (i.e., walking, ascending stairs, and descending stairs). The paper reports the validation of the controller through a set of experiments conducted with healthy participants. The proposed controller was tested for the first time with a unilateral leg exoskeleton assisting hip, knee, and ankle joints by delivering a fraction of the computed reference torques. Importantly, subjects performed a track involving ground-level walking, ascending stairs, and descending stairs and several transitions between these tasks. These experiments highlighted the capability of the controller to provide relevant assistive torques and to effectively handle transitions between the tasks. Subjects displayed a natural interaction with the device. Moreover, they significantly decreased the time needed to complete the track when the assistance was provided, as compared to wearing the device with no assistance

Research on Vegetation Coverage Dynamics and Prediction in the Taitema Lake Region

The Tarim River is the largest inland river in China, which plays a crucial role in maintaining regional ecological security and carbon cycle/dynamic. However, the “green corridor” in the Taitema Lake region at the lower reaches of the Tarim River has unclear environmental changes and future dynamics due to the influence of the ecological water conveyance. Hence, protecting the “green corridor” at the lower reaches of the Tarim River in China is strategically important not only ecologically but also socially and economically. In this paper, the temporal and spatial features of the fractional vegetation coverage (FVC) dynamics in the Taitema Lake region at the lower reaches of the Tarim River in 2000–2018 are analyzed and calculated using Landsat TM/OLI remote sensing images and MODIS data products. Additionally, the future trend of FVC dynamics in the study region are predicted using trend analysis and the pixel-based Hurst index. The results show that FVC in the Taitema Lake region exhibit a positive development after the implementation of ecological water conveyance. Specifically, from 2000 to 2018, the areas of low, medium, and high FVC expanded from 1.28 km2 to 179.87 km2, resulting in an increase of 140.52%. Spatially, the regions around the lake entrance channel of the Tarim River saw a significant increase in FVC of 9.71%. The middle part of the study region, accounting for only 1.96% of the area, displayed relatively high and high fluctuations in FVC. In the future, the regions at the middle part of the lake and around the lake entrance channel of the Tarim River, accounting for 11.33% of the area, will likely show an increasing trend in FVC. The regions with either extremely low or low FVC are predicted to decrease to 14.16% of the overall area. Because the positive effects of ecological water conveyance were more significant on FVC in the study region than the influences of either temperature or precipitation, ecological water conveyance should remain the primary means of ecological restoration for Taitema Lake

Research on Vegetation Coverage Dynamics and Prediction in the Taitema Lake Region

The Tarim River is the largest inland river in China, which plays a crucial role in maintaining regional ecological security and carbon cycle/dynamic. However, the “green corridor” in the Taitema Lake region at the lower reaches of the Tarim River has unclear environmental changes and future dynamics due to the influence of the ecological water conveyance. Hence, protecting the “green corridor” at the lower reaches of the Tarim River in China is strategically important not only ecologically but also socially and economically. In this paper, the temporal and spatial features of the fractional vegetation coverage (FVC) dynamics in the Taitema Lake region at the lower reaches of the Tarim River in 2000–2018 are analyzed and calculated using Landsat TM/OLI remote sensing images and MODIS data products. Additionally, the future trend of FVC dynamics in the study region are predicted using trend analysis and the pixel-based Hurst index. The results show that FVC in the Taitema Lake region exhibit a positive development after the implementation of ecological water conveyance. Specifically, from 2000 to 2018, the areas of low, medium, and high FVC expanded from 1.28 km2 to 179.87 km2, resulting in an increase of 140.52%. Spatially, the regions around the lake entrance channel of the Tarim River saw a significant increase in FVC of 9.71%. The middle part of the study region, accounting for only 1.96% of the area, displayed relatively high and high fluctuations in FVC. In the future, the regions at the middle part of the lake and around the lake entrance channel of the Tarim River, accounting for 11.33% of the area, will likely show an increasing trend in FVC. The regions with either extremely low or low FVC are predicted to decrease to 14.16% of the overall area. Because the positive effects of ecological water conveyance were more significant on FVC in the study region than the influences of either temperature or precipitation, ecological water conveyance should remain the primary means of ecological restoration for Taitema Lake

The Integration of Internet and Picture Book: Using Online Picture Book Reading Project to Promote Primary School Students’ Reading Literacy

This study aims to explore the effect of the combination of English picture books and the Internet on pupils’ English reading literacy. 12 primary school students participated in the online picture book reading project. The results are as follows: first, through pre-test and post-test, students’ reading comprehension ability has been improved; Second, the questionnaire shows the online project can help them increase reading interests, develop good reading habits and reading strategies; Last but not least, children give positive feedback to the project, especially about reading-guide videos and teachers’ comments in pronunciation. In general, the online project can promote pupils’ reading literacy

Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition In-Vitro and In-Vivo

Background: Epithelial-to-mesenchymal transition (EMT) is a potential pathway leading to podocyte depletion and proteinuria in diabetic kidney disease (DKD). Here, we investigated the protective effects of Emodin (EMO) on high glucose (HG) induced-podocyte EMT in-vitro and in-vivo. Methods: Conditionally immortalized mouse podocytes were exposed to HG with 30μg /ml of EMO and 1μmol/ml of integrin-linked kinase (ILK) inhibitor QLT0267 for 24 h. Streptozotocin (STZ)-induced diabetic rats were treated with EMO at 20 mg· kg-1· d-1 and QLT0267 at 10 mg· kg-1· w-1 p.o., for 12 weeks. Albuminuria and blood glucose level were measured. Immunohistochemistry, immunofluorescence, western blotting and real-time PCR were used to detect expression of ILK, the epithelial marker of nephrin and the mesenchymal marker of desmin in-vitro and in-vivo. Results: HG increased podocyte ILK and desmin expression while decreased nephrin expression. However, EMO significantly inhibited ILK and desmin expression and partially restored nephrin expression in HG-stimulated podocytes. These in-vitro observations were further confirmed in-vivo. Treatment with EMO for 12 weeks attenuated albuminuria, renal histopathology and podocyte foot process effacement in diabetic rats. EMO also repressed renal ILK and desmin expression, preserved nephrin expression, as well as ameliorated albuminuria in STZ-induced diabetic rats. Conclusion: EMO ameliorated glucose-induced EMT and subsequent podocyte dysfunction partly through ILK and desmin inhibition as well as nephrin upregulatiotion, which might provide a potential novel therapeutic option for DKD